The myths surrounding mild stimulation in vitro fertilization (IVF)
نویسندگان
چکیده
So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction.
منابع مشابه
Resurgence of Minimal Stimulation In Vitro Fertilization with A Protocol Consisting of Gonadotropin Releasing Hormone-Agonist Trigger and Vitrified-Thawed Embryo Transfer
Minimal stimulation in vitro fertilization (mini-IVF) consists of a gentle controlled ovarian stimulation that aims to produce a maximum of five to six oocytes. There is a misbelief that mini-IVF severely compromises pregnancy and live birth rates. An appraisal of the literature pertaining to studies on mini-IVF protocols was performed. The advantages of minimal stimulation protocols are report...
متن کاملComparison of The Effectiveness of Clomiphene Citrate versus Letrozole in Mild IVF in Poor Prognosis Subfertile Women with Failed IVF Cycles
Background Our objective was to evaluate the effectiveness of clomiphene citrate (CC) vs. letrozole (L) plus human menopausal gonadotropin (hMG) in gonadotropin releasing hormone (GnRH) antagonist protocol in poor prognosis women with previous failed ovarian stimulation undergoing intracytoplasmic sperm injection (ICSI). MaterialsAndMethods This retrospective cohort study included cycles with C...
متن کاملMild ovarian stimulation for in vitro fertilization: are we ready to change? A meta-analysis.
OBJECTIVE To compare the efficacy of mild ovarian stimulation versus conventional stimulation in in vitro fertilization (IVF). DESIGN Meta-analysis. SEARCH STRATEGY A systemic literature search was carried out for prospective randomised clinical trials. We electronically searched using PubMed, Medline and Embase for all the studies published from 1990 to December 2011. INTERVENTIONS Mild ...
متن کاملO-30: The Correlation between Myometrial Thickness and In Vitro Fertilization/ Intracyto- Plasmic Sperm Injection (IVF/ ICSI) Outcomes
Background O-30: The Correlation between Myometrial Thickness and In Vitro Fertilization/ Intracyto- Plasmic Sperm Injection (IVF/ ICSI) Outcomes MaterialsAndMethods In this prospective cohort study, 453 infertile women undergoing IVF-ET/ICSI cycles without any obvious pathology of uterine were enrolled. Trans-vaginal ultrasounds were conducted on days 2-4 of the cycle (menstrual phase) precedi...
متن کامل